Is PHMB or PHMG safe?

Polyhexamethylene biguanide (PHMB),

Basic information

Polyhexamethylene biguanide (PHMB) also called polyaminopropyl biguanide (PAPB) in the cosmetics industry. It is a new, highly effective and multi-purpose polymer, which is a cationic surfactant. Due to its high molecular polymer structure, the effective activity of the guanidine group can be improved, and its bactericidal efficacy is higher than that of other guanidines. At the same time, the active guanidine group can make the polymer positive and easy to be negatively charged by various bacteria , The virus is adsorbed and acts on the cell wall or cell membrane system of bacteria, fungi, algae, and combines with cell phospholipid compounds to quickly penetrate their membrane system, causing intracellular material to flow out of the bacteria, and inhibiting the activity of certain enzymes attached to the cell membrane , Thereby inhibiting the division function of bacteria and viruses, causing the bacteria and viruses to lose their ability to reproduce, and the film formed by the polymer blocks the breathing channels of microorganisms, causing the microorganisms to quickly suffocate and die, thereby achieving the antibacterial and anti-mildew effects. Moreover, the sterilization process belongs to physical sterilization, and bacteria are not easy to develop drug resistance.

Features:

Safe and stable, broad-spectrum sterilization, high-efficiency and long-lasting, environmentally friendly, non-corrosive, and a wide range of

applications:

Polyhexamethylene biguanide is a new type of polymer antiseptic and preservative, compatible with non-ionic surfactants and ethylene dichloride. Alcohols, glycol ethers, chelating agents (such as EDTA, IDS, etc.) and most strong acids. Limited compatibility with anionic surfactants, strong alkalis, phosphates and strong oxides. Compared with quaternary ammonium salt disinfectants, the odor and foam are greatly reduced, and the active ingredients have good high temperature stability and are not volatile. Mainly used in the fields of public and private hygiene, veterinary hygiene, agriculture, food and feed, canned preservatives, logistics and transportation, film preservatives and drinking water.

Polyhexamethylene guanidine (PHMG)

Polyhexamethylene guanidine LD50 is greater than 5000mg/kg, it belongs to the actual non-toxic level. Principles and characteristics are almost the same as PHMB. In terms of application, PHMB can be used for contact lens (care) solution, while PHMG Generally not used in this product and PHMG as a microbial disinfectant cannot be used in humidifiers.It is the “culprit” of the “Korean incident”. Regarding the “Korea Humidifier Incident”, I personally think that the main problem lies in the use of polyhexamethylene guanidine. Polyhexamethylene guanidine was used as a bactericide and added to the humidifier. Any substance that is atomized into fine particles that can be breathed into the human body will cause harm to the human body. For example, there is no problem with drinking alcohol. If it is atomized into fine particles that can be inhaled into the human body, it will also cause damage to the lungs. The main problem lies in the concentration and method of use. The product itself is safe under the correct use method and standard safe use concentration.

The main difference of PHMB and PHMG

The main difference between PHMB and PHMG is that the molecular structure is different, the synthesis process is different, and the scope of some applications is different.

Author: Changan Source: Zhihu

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