What should you consider when you are choosing a preservative?

Mild, Effective and Safe

February 8, 2022
4:19 am

Mild preservative

How to choose a mild preservative?

-stimulus study

-Allergy verification

    Chick embryo chorioallantoic membrane blood vessel test:Comparison of experimental results and judge it is non-irritating or irritating

-direct peptide reaction assay

Preservatives cause allergic positive reactions in descending order:

-Formaldehyde

-Benzalkonium Chloride

-CG Kathon CG 5.5%

-DMDM hydantoin

-Paraben mix

-Imidazolidinyl urea

-Quaternium 15

-Triclosan

The preservatives we try to avoid are: Benzalkonium chloride, KathonCG isothiazolinone, formaldehyde releaser (DMDM Hydantoin), Nepal gold ester, etc.

When choosing skin care products, try to choose products with mild preservatives

–Sodium Benzoate: The acid system effect is strong, and it is also commonly used as a preservative in food. Some big-name skin care products favor these types of preservatives. Such as Lancome’s new essence base liquid, sea blue mystery essence cream.

–Phenoxyethanol: Masks, day creams, and baby skin care products are often added.

Effective preservative

How to choose a effective preservative?

-Strong R&D

-Excellent compatibility and stability:

Product stability

product solubility

Product compatibility

-Multi-angle microbiological evaluation

Anti-corrosion function evaluation

Total bacterial colonies, total fungal colonies

Bactericidal (antibacterial) test

Antibacterial ring test: comparison of test results with no bacteriostatic effect or bacteriostatic effect

Gram stain microscopy

There are two types of preservatives. The first type of preservative is relatively aggressive and can directly damage cell walls, interfere with metabolic pathways, and kill microorganisms. Another preservative that creates an environment in which microorganisms cannot survive. Thereby reducing or inhibiting its reproductive capacity, microorganisms in a difficult living environment, the population decreases and slowly disappears.

Safe preservative

How to choose a safe preservative?

-A global regulatory perspective

-Authoritative Security Data

-Strict Quality Control

Content testing, analysis of prohibited and restricted substances

Refractive index

Absorbance

melting point

Are preservatives really irritating?

The answer is yes. But the formulators who talk about stimulation without talking about dosage are all hooligans.

Preservatives that can be used in skin care products have been evaluated, tested for safety, and comply with the regulations of the country of manufacture.

Of course, there are also preservatives that are found to be irritating to the human body after many years, and these countries or organizations will evaluate and modify the regulations. Different countries have slightly different regulations, and there will also be differences in the content or prohibition of certain types of preservatives.

Experienced formulators will usually use compounding methods to achieve the purpose of broad-spectrum antibacterial and reduce irritation.